Cell Therapy Durability Response Summit USA 2023

Cell Therapy Durability Response

Thank you for attending the Cell Therapy Durability Response Summit. Please check out our sister event, the Onco Cell Therapy Summit USA in June 2023

Onco Cell Therapy Summit USA 2023

“I thought it was well organized, and a nice size for networking and discussion, and the quality of the presentations was high”

James Tasker, Ziopharm Oncology (Onco Cell Therapy Summit USA 2021 attendee)

AUDIENCE BREAKDOWN

45%
Biotech
25%
Pharma
10%
Academic
20%
Vendors

Biotech

Pharma

Academic

Vendors

OUR CELL THERAPY COMMUNITY

  • 23+ senior-level speakers
  • Researchers from cell therapy biotechs
  • Representatives from pharmaceutical companies in the cell therapy space
  • Academic experts
  • R&D solution providers

Previous Cell Therapy Series Attendees:

Our 2022 Speakers

 

Vicki Plaks

Sr. Director, Cell Therapy, Oncology Discovery
AbbVie

Vicki Plaks

Sr. Director, Cell Therapy, Oncology Discovery
AbbVie

Vicki Plaks

Sr. Director, Cell Therapy, Oncology Discovery
AbbVie
 

Justin Edwards

Director of Cell Biology
Arcellx

Justin Edwards

Director of Cell Biology
Arcellx

Justin Edwards

Director of Cell Biology
Arcellx
 

Karrie Wong

Director of Cell Therapy
KSQ Therapeutics

Karrie Wong

Director of Cell Therapy
KSQ Therapeutics

Karrie Wong

Director of Cell Therapy
KSQ Therapeutics
 

Jonathan Gilbert

VP of Exploratory Research
SQZ Biotechnologies

Jonathan Gilbert, PhD joined SQZ in 2013 and has been a key player in the growth and development of the company from its formative stages. As the Vice President of Exploratory Research, he is applying the Cell Squeeze Technology to generate new cell therapy concepts in multiple disease areas from cancer to regenerative medicine. In previous roles he lead Business Development as well as managing active partnerships such as the >$1B Collaboration with Roche. Dr.

Jonathan Gilbert

VP of Exploratory Research
SQZ Biotechnologies

Jonathan Gilbert

VP of Exploratory Research
SQZ Biotechnologies

Jonathan Gilbert, PhD joined SQZ in 2013 and has been a key player in the growth and development of the company from its formative stages. As the Vice President of Exploratory Research, he is applying the Cell Squeeze Technology to generate new cell therapy concepts in multiple disease areas from cancer to regenerative medicine. In previous roles he lead Business Development as well as managing active partnerships such as the >$1B Collaboration with Roche. Dr. Gilbert received his PhD in Chemical Engineering from MIT, where he was a Presidential Fellow, and studied biomedical applications of structured polyelectrolyte films with Professor Robert Cohen and Professor Michael Rubner. He has published over a dozen articles and is an inventor on 8 patents.

 

Samia Khan

Senior Scientist II
Editas Medicine

Samia Khan

Senior Scientist II
Editas Medicine

Samia Khan

Senior Scientist II
Editas Medicine
 

Sean Arlauckas

Director of Oncology
Be Biopharma

Sean Arlauckas

Director of Oncology
Be Biopharma

Sean Arlauckas

Director of Oncology
Be Biopharma
 

Geoff Hodge

CEO
SOTIO Biotech US

 

Geoff is the CEO of SOTIO Biotech US, a Cambridge, MA based subsidiary of SOTIO Biotech a.s. that is focused on the development of novel cell therapies to treat solid tumor cancers. He has over 30 years of experience in the biotechnology industry, providing bioprocessing technical solutions for companies including GE Healthcare Life Sciences (Cytiva), Millennium Pharmaceuticals (Takeda), Genetics Institute (Wyeth/Pfizer) and Alpha-Beta Technology. He is an inventor on more than a dozen bioprocess equipment and technology patents.

 

Geoff Hodge

CEO
SOTIO Biotech US

Geoff Hodge

CEO
SOTIO Biotech US

 

Geoff is the CEO of SOTIO Biotech US, a Cambridge, MA based subsidiary of SOTIO Biotech a.s. that is focused on the development of novel cell therapies to treat solid tumor cancers. He has over 30 years of experience in the biotechnology industry, providing bioprocessing technical solutions for companies including GE Healthcare Life Sciences (Cytiva), Millennium Pharmaceuticals (Takeda), Genetics Institute (Wyeth/Pfizer) and Alpha-Beta Technology. He is an inventor on more than a dozen bioprocess equipment and technology patents.

 

Prior to SOTIO, Geoff was Chief Technical Officer at Unum Therapeutics, where he managed all technical operations for the company—including process and analytical development, manufacturing, and quality—for the company’s clinical phase viral vector and T-cell processes, as well as overseeing corporate IT, facilities, and logistics. He was previously a co-founder of Xcellerex, a company pioneering single-use bioreactors, mixers, facilities, and GMP manufacturing services, featuring single-use manufacturing and high-throughput process development services. He is the inventor of record on multiple core technology patents for Xcellerex, and served as an operations leader at GE Healthcare Life Sciences after GE acquired Xcellerex. Geoff holds an M.S. in Biotechnology from WPI and Bachelor’s degree in Biology from Colgate University.

 

 

Camilla Fairbairn

Senior Scientist
bit.bio

Camilla Fairbairn

Senior Scientist
bit.bio

Camilla Fairbairn

Senior Scientist
bit.bio
 

Stefanie Mandl

SVP Research
PACT Pharma

Stefanie Mandl

SVP Research
PACT Pharma

Stefanie Mandl

SVP Research
PACT Pharma
 

John Rossi

VP Translational Medicine
Syncopation Life Sciences

John Rossi

VP Translational Medicine
Syncopation Life Sciences

John Rossi

VP Translational Medicine
Syncopation Life Sciences
 

Daniel Larcombe-Young

PhD Student & Scientific Consultant
Leucid Bio

Daniel Larcombe-Young

PhD Student & Scientific Consultant
Leucid Bio

Daniel Larcombe-Young

PhD Student & Scientific Consultant
Leucid Bio
 

Robert Brooks

CEO
Alphageneron

Robert Brooks

CEO
Alphageneron

Robert Brooks

CEO
Alphageneron
 

James Lederer

Chief Scientific Officer
Alloplex Biotherapeutics Inc.

James Lederer

Chief Scientific Officer
Alloplex Biotherapeutics Inc.

James Lederer

Chief Scientific Officer
Alloplex Biotherapeutics Inc.
 

Andrew Weinberg

President and CSO
AgonOx

In recent years we have been defining T cell populations within the blood and tumor of cancer patients to determine potential protein/pathways that could specifically target TIL therapeutically.  Our initial publication compared T cells from patients with colorectal liver metastatses and ovarian cancer.  We found several differences in the phenotype of CD8s, CD4s, and Tregs between the TIL and blood that were consistent between these two different types of tumors.  This suggested to us that two distinct tumor types were behaving very similar immunologically, hence one coul

Andrew Weinberg

President and CSO
AgonOx

Andrew Weinberg

President and CSO
AgonOx

In recent years we have been defining T cell populations within the blood and tumor of cancer patients to determine potential protein/pathways that could specifically target TIL therapeutically.  Our initial publication compared T cells from patients with colorectal liver metastatses and ovarian cancer.  We found several differences in the phenotype of CD8s, CD4s, and Tregs between the TIL and blood that were consistent between these two different types of tumors.  This suggested to us that two distinct tumor types were behaving very similar immunologically, hence one could potentially target them with the same immunotherapy agents (e.g. PD-1 blockade works for several different tumor types).  With this in mind we have found several new protein targets that we are exploring as therapeutic targets preclinically with this approach.  Upon further inspection with other tumor types and a deeper dive into the CD8 phenotype in tumors vs blood we discovered a unique CD8 T cell population that express both CD39 and CD103.  These T cells were only found in tumors and were highly enriched for tumor-reactivity.  The CD39/103 double CD8 TIL had both an activated and exhausted phenotype, suggesting that they had recently encountered the tumor Ag in situ.  Another unique finding was the highly clonal nature of these CD8 TIL when assessed directly ex vivo and these clones were found at very low frequency in the blood of cancer patients.  The data suggested that these cells make it into the tumor microenvironment and expand when they encounter their tumor Ag; however, chronic activation in the tumor might lead to exhaustion of this CD8 TIL population.  We have now been able to rescue/grow these cells in vitro and expand them from thousands of cells to billions in a 4-week span.  We have found that they can kill autologous tumors in vitro and make autologous tumors completely regress in tumor-bearing mice.  This data has set the stage for an adoptive T cell therapy clinical trial and will be performed with this tumor-reactive T cell population.  Our group has had a pre-IND discussion with the FDA earlier this year and are currently performing 3 qualifying runs, which should be completed by Jan 2022.  We intend to submit the IND for this clinical trial in early 2022 and commence with the trial soon thereafter.  

 

Raphaël Ognar

CEO
NKILT Therapeutics

Raphaël Ognar

CEO
NKILT Therapeutics

Raphaël Ognar

CEO
NKILT Therapeutics
 

Austin Bigley

VP of Research and Development
Indapta Therapeutics

Austin Bigley

VP of Research and Development
Indapta Therapeutics

Austin Bigley

VP of Research and Development
Indapta Therapeutics
 

Aviad Pato

Head of Research, Natural Killer Cells
Gamida Cell

Aviad Pato

Head of Research, Natural Killer Cells
Gamida Cell

Aviad Pato

Head of Research, Natural Killer Cells
Gamida Cell
 

Tina Sarén

Senior Scientist
Elicera Therapeutics

Tina Sarén

Senior Scientist
Elicera Therapeutics

Tina Sarén

Senior Scientist
Elicera Therapeutics
 

Jerry Zeldis

Executive Vice President, Research and Development
NexImmune

Jerry Zeldis

Executive Vice President, Research and Development
NexImmune

Jerry Zeldis

Executive Vice President, Research and Development
NexImmune

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Fill out this form to register your interest for our sister event, the Onco Cell Therapy Summit USA 2023. 

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In the event that Kisaco Research postpones an event for any reason or changes the event format to ‘virtual event’, any in-person registrations for this event will be automatically transferred to the virtual registration package. The delegate will receive a credit note for the difference in ticket value from the fee paid. You may use this credit for another Kisaco Research event to be mutually agreed with Kisaco Research, which must occur within 12 months from the date of the event which the delegate had originally registered for.

Why Attend

The current generation of CAR-T approaches for hematological malignancies generate strong responses in cancer patients, but too often progression-free survival is less than 12 months. The next-generation allogeneic approaches may make these therapies more accessible to the patients who need them but have been hampered by poor in vivo persistence. And so far, no cell therapy has been approved to tackle solid tumors, in part due to the immunosuppressive microenvironment and a strong ability for tumor antigen escape, both limiting the durability of therapeutic responses.

Durability is the #1 challenge for cell therapy – the Cell Therapy Durability Response Summit was the first conference to focus on this issue.

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